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M9480590.TXT
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1994-08-20
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Document 0590
DOCN M9480590
TI HIV-1 gp41 enhances major histocompatibility complex class I and ICAM-1
expression on H9 and U937 cells.
DT 9410
AU Chen YH; Bock G; Vornhagen R; Steindl F; Katinger H; Dierich MP; Ludwig
Boltzmann Institute for AIDS Research, Innsbruck, Austria.
SO Int Arch Allergy Immunol. 1994 Jul;104(3):227-31. Unique Identifier :
AIDSLINE MED/94305372
AB Based on our findings that HIV-1 (human immunodeficiency virus type 1)
soluble gp41 (sgp41; amino acids 539-684) bound to human T, B, and
monocyte cells and enhanced major histocompatibility complex (MHC) class
I and II antigen expression on Raji cells, we examined the effect of
HIV-1 sgp41 on the surface expression of MHC I and II, ICAM-1, and CD4
molecules on human H9 and U937 cells. Flow cytometry (FACS) analysis
demonstrated that sgp41 selectively enhanced MHC class I expression by
about 75% on H9 cells and by about 85% on U937 cells, while the ICAM-1
expression was increased by about 70% only on H9 cells and remained
unaltered on U937 cells; other molecules, such as MHC class II and CD4,
remained unaltered. By comparison, alpha-, beta-, and omega-interferons,
but not gamma-interferon, showed similar effects as sgp41 on the
expression of MHC class I and ICAM-1 on H9 and U937 cells. The results
suggest that HIV-1 gp41 may have a biological function that is involved
in the regulation of human MHC class I and ICAM-1 expression.
DE Antigens, CD/*METABOLISM Cell Adhesion Molecules/*METABOLISM Cell Line
Cells, Cultured Flow Cytometry Histocompatibility Antigens Class
I/*METABOLISM Human HIV Envelope Protein gp41/*PHARMACOLOGY *HIV-1
Interferon-alpha/PHARMACOLOGY Interferon-beta/PHARMACOLOGY
Interferon-gamma, Recombinant/PHARMACOLOGY Major Histocompatibility
Complex/*DRUG EFFECTS Monocytes/DRUG EFFECTS/METABOLISM Receptors,
Virus/*METABOLISM Support, Non-U.S. Gov't T4 Lymphocytes/DRUG
EFFECTS/METABOLISM JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).